Emerging Roles for PKC Isoforms in Immune Cell Function

  1. Thomas T. Su1,
  2. Beichu Guo2 and
  3. David J. Rawlings2,3
  1. 1The Molecular Biology Institute, University of California, Los Angeles, CA 90095-1752, USA, and
  2. 2Department of Immunology and
  3. 3Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA

Abstract

Two publications by Mecklenbräuker et al. and Miyamoto et al. describe an essential role for protein kinase Cδ (PKCδ) in the development of immune tolerance, and suggest that PKCδ also participates in mechanisms that prevent autoimmunity. Su, Guo, and Rawlings discuss these observations within the larger context of determining specific functions for individual isoforms of PKC in B and T lymphocytes, and the careful control these proteins exert in maintaining proper lymphocyte activation and tolerance.

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This Article

  1. doi: 10.1124/mi.2.3.141 MI June 2002 vol. 2 no. 3 141-144
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