Increased Expression and Function of Vascular α_1D-Adrenoceptors May Mediate The Prohypertensive Effects Of Angiotensin II

Abstract

The peptide Angiotensin II (Ang II), part of the renin-angiotensin system (RAS), participates in the control of systemic arterial pressure. Ang II participates in increasing smooth muscle tone, and its positive effects on smooth muscle cell DNA synthesis are inhibited by treatment with prazosin, an α₁-adrenoceptor agonist. Ang II also induces the expression of α₁-adrenoceptor, especially the α_1D subtype. Other findings suggest that the molecular signals activated by Ang II and by α_1D-adrenoceptor might interweave, thus leading to the augmentation of smooth muscle tone and hypertension.