sorLA: Sorting Out APP

Abstract

The accumulation of amyloid-β peptides in the brain is a major factor of Alzheimer Disease. Central to the production of the amyloid-β peptides are the proteolytic secretases, which, recently, have been important targets of drug discovery. Newly published results indicate that the sorting protein-related receptor sorLA/LR11 regulates processing and trafficking of the precursor of the amyloid-β peptides, revealing an alternative target for developing molecular clinical therapeutic compounds for Alzheimer Disease.