Dedifferentiation? What’s next?

  1. Sungwoo Kim1,
  2. Gus R. Rosania2 and
  3. Young-Tae Chang3
  1. 1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037;
  2. 2Department of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, MI 48109;
  3. 3Department of Chemistry, New York University, NY, NY 10003


Not so fast! Several things need to be considered before we conclude that Chen et al. have a dedifferentiating agent on their hands. The verification of small molecules as tissue- or cell-type dedifferentiating agents will require greatly sophisticated techniques and the identification of the direct molecular targets of said small molecules. By knowing what pitfalls to avoid, intelligent small-molecule design and testing may proceed more expediently.

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