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Selected Factors That Influence Responses to AntihypertensivesChoosing Therapy for the Uncomplicated Patient
Barry L. Carter, PharmD;
Edward D. Frohlich, MD;
William J. Elliott, MD, PhD;
Michael A. Moore, MD;
R. Jerry Mann, MD;
Raymond W. Roberts, PharmD
Arch Fam Med. 1994;3(6):528-535.
Abstract
Numerous factors may influence an individual patient's response to antihypertensive therapy. The physician should select therapy that is more likely to effectively control the patient's blood pressure. In addition to age and race, specific properties of the drugs plus the method of administration can influence response. Most antihypertensives can be given once or twice daily without the need for sustained-release dosage forms. The appropriate selection of regular-release products can significantly reduce the cost of therapy and improve adherence to the regimen. Because most antihypertensives exist as isomers of two compounds, response to a given agent can be influenced by the type of product (eg, sustainedrelease) or the method of administration. When these variables are considered for individual patients, it is more likely that a given drug will be effective.
Author Affiliations
From the Department of Pharmacy Practice, University of Illinois at Chicago (Dr Carter); the Department of Preventive Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago (Dr Elliot); the Alton Ochsner Medical Foundation, New Orleans, La (Dr Frohlich); the Department of Medicine, Bowman Gray School of Medicine, Winston-Salem, NC (Dr Moore); the Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill (Dr Moore); the Department of Nephrology, Danville (Va) Urologic Clinic (Dr Moore); the Department of Family and Community Medicine, University of Arkansas for Medical Sciences, Little Rock (Dr Mann); and Home Infusion Services, Foxmeyer Corporation, Carrollton, Tex (Dr Roberts).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Hydrochlorothiazide Versus Chlorthalidone: Evidence Supporting Their Interchangeability
Carter et al.
Hypertension 2004;43:4-9.
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