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The P-450 SystemDefinition and Relevance to the Use of Antidepressants in Medical Practice
Richard J. Goldberg, MD
Arch Fam Med. 1996;5(7):406-412.
Abstract
Over the last several years, several new antidepressants have been introduced into primary care practice. A number of these, including the selective serotonin reuptake inhibitors and nefazodone, have some common and potentially significant drug interactions as a result of interference with components of the hepatic P-450 enzyme system. This review provides information on those drugs that interfere with P-450 function (inhibitors), as well as those substrates whose metabolism can be impaired by P-450 inhibitors. Because it is important for primary care clinicians to be aware of these interactions, this article presents a review of the P-450 system and its relevance to the use of antidepressants in medical practice.
Author Affiliations
From the Departments of Medicine and Psychiatry, Brown University; Rhode Island Hospital; and Women & Infants' Hospital, Providence, RI.
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