Graft

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to register today!

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wilkes, D. S.
Right arrow Search for Related Content
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Graft, Vol. 6, No. 1, 42-49 (2003)
DOI: 10.1177/1522162802239756
© 2003 SAGE Publications

Autoimmune Responses to Grafted Lungs: Immune Responses to a Native Collagen—Type V Collagen

David S. Wilkes, MD

Indiana University School of Medicine

Lung transplantation is the only definitive treatment modality for many forms of end-stage lung disease. However, the lung is rejected more often than any other type of solid organ allograft due to chronic rejection known as bronchiolitis obliterans (BO). Indeed, BO is the primary reason why the 5- and 7-year survival rates are worse than any other transplanted organs. Alloimmunity to donor antigens is established as the primary mechanism that mediates rejection responses. However, newer immunosuppressive regimens designed to abrogate alloimmune activation have not improved survival. Therefore, these data suggest that other antigens, unrelated to donor transplantation antigens, are involved in rejection. Utilizing human and rodent studies of lung transplantation, our laboratory has documented that a native collagen, type V collagen (col(V)), is a target of the rejection response. Since col(V) is highly conserved, these data indicate that transplant rejection involves both alloimmune and autoimmune responses. The role of col(V) in lung transplant rejection is described in this review article.

Key Words: autoimmunity • type V collagen • allorecognition • lung transplantation

References

  • 1. Hosenpud JD, Bennett LE, Keck BM, Boucek MM, Novick RJ. The registry of the International Society for Heart and Lung Transplantation: eighteenth official report—2001 . J Heart Lung Transplant 2001;20: 805 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 2. Keenan RJ, Zeevi A. Immunologic consequences of transplantation . Chest Surg Clin N Am 1995;5: 107 .[Medline] [Order article via Infotrieve]OpenURL
  • 3. Haque MA, Mizobuchi T, Yasufuku K, Fujisawa T, Brutkiewicz RR, Zheng Y, et al. Evidence for immune responses to a self-antigen in lung transplantation: role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection . J Immunol 2002;169: 1542 .[Abstract/Free Full Text]
  • 4. Yasufuku K, Heidler KM, Woods KA, Smith GN, Jr., Cummings OW, Fujisawa T, et al. Prevention of bronchiolitis obliterans in rat lung allografts by type V collagen-induced oral tolerance . Transplantation 2002;73: 500 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 5. Yasufuku K, Heidler KM, O’Donnell PW, Smith GN, Jr., Cummings OW, Foresman BH, et al. Oral tolerance induction by type V collagen downregulates lung allograft rejection . Am J Respir Cell Mol Biol 2001;25: 26 .[Abstract/Free Full Text]
  • 6. Mares DC, Heidler KM, Smith GN, Cummings OW, Harris ER, Foresman B, et al. Type V collagen modulates alloantigen-induced pathology and immunology in the lung . Am J Respir Cell Mol Biol 2000;23: 62 .[Abstract/Free Full Text]
  • 7. van Kuppevelt TH, Veerkamp JH, Timmermans JA. Immunoquantification of type I, III, IV and V collagen in small samples of human lung parenchyma . Int J Biochem Cell Biol 1995;27: 775 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 8. Konomi H, Hayashi T, Nakayasu K, Arima M. Localization of type V collagen and type IV collagen in human cornea, lung, and skin. Immunohistochemical evidence by anti-collagen antibodies characterized by immunoelectroblotting . Am J Pathol 1984;116: 417 .[Abstract]
  • 9. Madri JA, Furthmayr H. Isolation and tissue localization of type AB2 collagen from normal lung parenchyma . Am J Pathol 1979;94: 323 .[Abstract]
  • 10. Madri JA, Furthmayr H. Collagen polymorphism in the lung. An immunochemical study of pulmonary fibrosis . Hum Pathol 1980;11: 353 .[Medline] [Order article via Infotrieve]OpenURL
  • 11. Cremer MA, Ye XJ, Terato K, Owens SW, Seyer JM, Kang AH. Type XI collagen-induced arthritis in the Lewis rat. Characterization of cellular and humoral immune responses to native types XI, V, and II collagen and constituent alpha-chains . J Immunol 1994;153: 824 .[Abstract]
  • 12. Hanson IM, Gorman P, Lui VC, Cheah KS, Solomon E, Trowsdale J. The human alpha 2(XI) collagen gene (COL11A2) maps to the centromeric border of the major histocompatibility complex on chromosome 6 . Genomics 1989;5: 925 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 13. Luz JG, Huang M, Garcia KC, Rudolph MG, Apostolopoulos V, Teyton L, Wilson IA. Structural comparison of allogeneic and syngeneic T cell receptorpeptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions . J Exp Med 2002;195: 1175 .[Abstract/Free Full Text]
  • 14. Wilkes DS, Heidler KM, Bowen LK, Quinlan WM, Doyle NA, Cummings OW, et al. Allogeneic bronchoalveolar lavage cells induce the histology of acute lung allograft rejection, and deposition of IgG2a in recipient murine lungs . J Immunol 1995;155: 2775 .[Abstract]
  • 15. Zucker S, Hymowitz M, Conner C, Zarrabi HM, Hurewitz AN, Matrisian L, et al. Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications . Ann N Y Acad Sci 1999;878: 212 .[Abstract/Free Full Text]
  • 16. Trello CA, Williams DA, Keller CA, Crim C, Webster RO, Ohar JA. Increased gelatinolytic activity in bronchoalveolar lavage fluid in stable lung transplant recipients . Am J Respir Crit Care Med 1997;156: 1978 .[Abstract/Free Full Text]
  • 17. Harris PE, Cortesini R, Suciu-Foca N. Indirect allorecognition in solid organ transplantation . Rev Immunogenet 1999;1: 297 .[Medline] [Order article via Infotrieve]OpenURL
  • 18. Hernandez-Fuentes MP, Baker RJ, Lechler RI. The alloresponse . Rev Immunogenet 1999;1: 282 .[Medline] [Order article via Infotrieve]OpenURL
  • 19. Sayegh MH. Why do we reject a graft? Role of indirect allorecognition in graft rejection . Kidney Int 1999;56: 1967 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 20. Tejani A, Emmett L. Acute and chronic rejection . Semin Nephrol 2001;21: 498 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 21. Heidler KM, Baker K, Woods K, Schnizlein-Bick C, Cummings OW, Sidner R, et al. Instillation of allogeneic lung antigen-presenting cells deficient in expression of major histocompatibility complex class I or II antigens have differential effects on local cellular and humoral immunity and on pathology in recipient murine lungs . Am J Respir Cell Mol Biol 2000;23: 499 .[Abstract/Free Full Text]
  • 22. Valujskikh A, Fedoseyeva E, Benichou G, Heeger PS. Development of autoimmunity after skin graft rejection via an indirect alloresponse . Transplantation 2002;73: 1130 .[Medline] [Order article via Infotrieve]OpenURL
  • 23. Fedoseyeva EV, Kishimoto K, Rolls HK, Illigens BM, Dong VM, Valujskikh A, et al. Modulation of tissue-specific immune response to cardiac myosin can prolong survival of allogeneic heart transplants . J Immunol 2002;169: 1168 .[Abstract/Free Full Text]
  • 24. Ishido N, Matsuoka J, Matsuno T, Nakagawa K, Tanaka N. Induction of donor-specific hyporesponsiveness and prolongation of cardiac allograft survival by jejunal administration of donor splenocytes . Transplantation 1999;68: 1377 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 25. Garcia G, Weiner HL. Manipulation of Th responses by oral tolerance . Curr Top Microbiol Immunol 1999;238: 123 .[Medline] [Order article via Infotrieve]OpenURL
  • 26. Weiner HL. Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells . Microbes Infect 2001;3: 947 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 27. Zhang X, Izikson L, Liu L, Weiner HL. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration . J Immunol 2001;167: 4245 .[Abstract/Free Full Text]
  • 28. Weiner HL. Oral tolerance, an active immunologic process mediated by multiple mechanisms . J Clin Invest 2000;106: 935 .[Free Full Text]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?



This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wilkes, D. S.
Right arrow Search for Related Content
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?