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Recurrence of Disease after Liver Transplantation

Liver Unit Queen Elizabeth Hospital

Geoffrey H. Haydon, MRCP, MD

Liver Unit Queen Elizabeth Hospital, geoffhay{at}email.msn.com

Recurrent hepatitis B and C is common following liver transplantation. Autoimmune disease manifests as primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis. Metabolic diseases, such as hemochromatosis, Wilson's disease, amyloidosis, and alcoholic liver disease (ALD) also recur. Recurrent malignancy also is reported. Liver transplantation is potentially curative in a subset of patients with hepatocellular carcinoma (HCC) with a small tumor burden. Survival after transplantation is 53%-72% after 1 year and 17%-25% after 5 years. Many cases of cryptogenic cirrhosis are due to clandestine NASH.

Key Words: liver transplantation • cirrhosis • hepatitis

References

• 1. Perrillo R, Rakela J, Dienstag J, et al. Multicenter study of lamivudine for hepatitis B after liver transplantation. Hepatology 1999;29:1581-1586.[Medline] [Order article via Infotrieve]
• 2. Samuel D, Muller R, Alexander G, et al. Liver transplantation in European patients with the hepatitis B surface antigen. N Engl J Med 1993; 329:1842-1847.[Abstract/Free Full Text]
• 3. Ottobrelli A, Marzano A, Smedlie A, et al. Patterns of hepatitis Delta virus re-infection and disease in liver transplantation. Gastroenterology 1991;101:1649-1655.[Medline] [Order article via Infotrieve]
• 4. Feray C, Caccamo L, Alexander GJM, et al. European collaborative study on factors influencing outcome after liver transplantation for hepatitis C. Gastroenterology 1999;117:619-625.[CrossRef][Medline] [Order article via Infotrieve]
• 5. Ratziu V, Samuel D, Sebagh M, et al. Long-term follow-up after liver transplantation for autoimmune hepatitis: evidence of recurrence of primary disease. J Hepatol 1999;30:131-141.[Medline] [Order article via Infotrieve]
• 6. Forman LM, Lewis JD, Berlin JA, Feldman HA, Lucey MR. The association between hepatitis C infection and survival after orthotopic liver transplantation. Gastroenterology 2002;122:889-896.[CrossRef][Medline] [Order article via Infotrieve]
• 7. Harrison RF, Davies MH, Neuberger JM, et al. Fibrous and obliterative cholangitis in liver allografts: evidence for recurrent primary sclerosing cholangitis. Hepatology 1994;20:35661.
• 8. Garcia RFL, Garcia CE, McMaster P, Neuberger J. Transplantation for primary biliary cirrhosis: retrospective analysis of 400 patients in a single center. Hepatology 2001;33:22-27.[Medline] [Order article via Infotrieve]
• 9. Brandhagen DJ, Alvarez W, Therneau TM, et al. Iron overload in cirrhosis-HFE genotypes and outcome after liver transplantation. Hepatology 2000;31:456-460.[Medline] [Order article via Infotrieve]
• 10. Schilsky ML, Scheinberg IH, Sternlieb I. Liver transplantation for Wilson's disease: indications and outcome. Hepatology 1994;19:583-587.[Medline] [Order article via Infotrieve]
• 11. Suhr OB, Herlenius G, Friman S, et al. Liver transplantation for hereditary transthyretin amyloidosis. Liver Transplant 2000;6:263-276.[CrossRef][Medline] [Order article via Infotrieve]
• 12. Lucey MR, Carr K, Beresford TP, et al. Alcohol use after liver transplantation in alcoholics: a clinical cohort follow-up study. Hepatology 1997;25:1223-1227.[CrossRef][Medline] [Order article via Infotrieve]
• 13. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996;334:693-699.[Abstract/Free Full Text]
• 14. Lehnert T. Liver transplantation for metastatic neuroendocrine carcinoma: an analysis of 103 patients. Transplantation 1998;66:1307-1312.[CrossRef][Medline] [Order article via Infotrieve]
• 15. Charlton M, Kasparova P, Weston S, et al. Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease. Liver Transplant 2001;7:608-614.[CrossRef][Medline] [Order article via Infotrieve]

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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Reprints and Permissions Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Forman, L. Articles by Haydon, G. H. Search for Related Content Social Bookmarking                   What's this?