Macromolecular Therapeutics

TABLE 1.

The Rule of Five

Desirable Characteristics of Conventional Candidate Drugs
ac log P is a proportional index of drug solubility in aqueous relative to non-aqueous solvent.
≤ 5 H-bond donors
Molecular weight ≤ 500
c log P ≤ 5a
Total number of nitrogen and oxygen atoms ≤ 10

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  1. MI April 2001 vol. 1 no. 1 40-53
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