Macromolecular Therapeutics

TABLE 2.

Cell-Penetrating Peptides Under Investigation

Source	Sequence	Delivery Applications
^a From the human immunodeficiency virus (66).
^b From the herpes simplex virus (66).
^c A postulated mimimal sequence (66).
^d From Drosophila (66).
^e See (83).
^f A typical sequence (67).
Tat^a	YGRKKRQRRR	Peptides, oligonucleotides, proteins
VP22^b	DAAWAWGRGRSAASRPW	Proteins
	ERPRAPARSASRPRPPVE^c
Antennepedia^d	RQIKIWFQNRRMKWKK	Peptides, oligonucleotides
Diptheria Toxin Trans Domain^e	~100 amino acids	Proteins
Signal-sequence peptides^f	AAVALLPAVLLALL	Peptides, proteins
	APVQRKRQKLMP