γ-Secretase: A Catalyst of Alzheimer Disease and Signal Transduction

Proteolytic processing of APP. Two pathways of APP processing have been established. APP is cleaved at the extracellular site by α- or β-secretase followed by γ-secretase to release P3 or Aβ peptides, respectively. Thus, inhibition of β- and /or γ-secretase (and activation of α-secretase) will reduce the production of Aβ.