Neurological Disease: Listening to Gene Silencers

Table 1.

Selected NRSE-Containing Genes of Interest to Neuroscience

Gene product Speciesa Gene product Speciesa
aR, M, and H refer to rat, mouse, and human genes, respectively. bFunctional silencing activity of RE1-like element was demonstrated.
Acetylcholine receptor, β2 nicotinic RMbHb Na+ channel PN3 (TTX resistant) R
Acetylcholine receptor, M4 muscarinic Rb Na+ channel Type II Rb
Arginine vasopressin Hb Na+ channel type X, α subunit R
Atrial natriuretic peptide Rb Na+, K+-ATPase, α3-subunit Mb
BDNF RMb Neurexin IIIα H
Ca2+ ATPase, calmodulin-sensitive R Neuronal proliferation differentiation
Ca2+ channel (T-type, α1H) M     control-1 protein (Npdc1) M
Cadherin 13 M Opioid receptor (mu 1) RHb
Calbindin Mb Oxysterol binding protein 2 H
CaM kinase R Pentraxin 2, neuronal M
CaM-Kinase II inhibitor α R Pentraxin receptor, neuronal M
CART protein R Prolactin-releasing peptide receptor R
catenin II αN M Protocadherin 8 RH
Cdc42 GTPase-inhibiting protein M Rab3D M
CDK5 activator M RAN binding protein 16 H
Choline acetyltransferase Rb Rap2 interacting protein 8 H
Connexin 57 M Rb-8 neural cell adhesion protein M
Connexin 62 H SCG10 Rb
Corticotropin releasing hormone RMbH Sec 6 M
Dopamine-β-hydroxylase Hb Secretogranin II RM
Dynamin I Mb Serotonin receptor 5-HT1A R
Dynein, heavy chain M Serotonin transporter M
GABAAa receptor δ subunit Rb Somatostatin R
GABAAa receptor γ2 subunit Hb Somatotropin hormone H
Gap junction protein α10 M Spermidine synthase H
Gephyrin H STAT6 M
Glutamate receptor GluR2 RbM Synapsin Hb
Glutamate receptor KA2 RM Synaptophysin Rb
Glutamate receptor KA5 RM Synaptotagmin IV RMH
Glutamate receptor NMDAR1 RbH Synaptotagmins 6 and 13 R
Glutamate receptor NMDAR2B Rb Syntaxin binding protein 1 MH
Glutamate receptor NMDAR2C Rb Taste receptor type I (T1r3) M
Glycine receptor α1 H TNF receptor 6b H
Glycine receptor α3 RbHb Toll-like receptor 8 H
Huntingtin associated protein RMH Transcription factor HES-3 RM
Insulin receptor H Transcription factor NeuroD R
K+ channel β1 (Shaker related) M Transcription factors E2F and POU4F3 H
K+ channel KCNQ1 R TRP3 receptor-activated cation channel M
L1 neural cell adhesion molecule MHb Tyrosine kinase Ack M
LIM-3 homeoprotein M Tyrosine kinase ALK M
Melatonin receptor 1B H Vanniloid receptor-like protein 1 RM

This Article

  1. MI October 2001 vol. 1 no. 4 219-228