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Bisphosphonate Therapeutics in Bone Disease: The Hard and Soft Data on Osteoclast Inhibition
Table 1
Bisphosphonate Structures and Relative Activities
| Bisphosphonate | –R1 | –R2 | Relative potency |
|---|---|---|---|
| Etidronate | –OH | –CH3 | 0.01 |
| Clodronate | –CI | –CI | 0.1 |
| Tiludronate | –H |  |
0.1 |
| Pamidronate | –OH | –(CH2)2–NH2 | 1 |
| Alendronate | –OH | –(CH2)3–NH2 | 5 |
| Ibandronate | –OH |  |
10 |
| Risedronate | –OH |  |
20 |
| Zoledronate | –OH |  |
100 |
