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Characterizing Proteins of Unknown Function: Orphan Cytochrome P450 Enzymes as a Paradigm
Table 1
Human P450 Orphans
| P450 | Site(s) of Expression | Possible Substrates |
|---|---|---|
| 2A71 | ||
| 2S1 | Skin, liver (also trachea, lung, stomach, small intestine, spleen) (74, 76) | (Retinoic acid, carcinogens?) (72, 76–78, 81) |
| 2U1 | Thymus, brain (56, 57) | Fatty acids (ω, ω-1) (56, 57) |
| 2W1 | Tumors (72, 73) | Carcinogens (72) |
| 3A431 | ||
| 4A221 | ||
| 4F11 | Liver (86) | Fatty acids (ω-1, -2, -3...), β-hydroxy fatty acids (33, 55) |
| 4F221 | ||
| 4V2 | Eye (87) | Fatty acids (ω) (58) |
| 4X1 | Brain, liver (59) | Anandamide (59) |
| 4Z1 | Breast cancer (88) | Fatty acids (ω-2, -3, -4, -5) (60) |
| 20A1 | Brain, liver (84) | (Unknown) (84) |
| 27C1 | Liver, kidney, spleen, others (85) | (Unknown) (85) |
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↵1 The literature is not clear whether these are expressed.
