Antioxidants in Hypertension and Cardiovascular Disease
Figure 1
Atherogenesis exemplifies mechanisms of ROS signaling and damage in the cardiovascular system. Superoxide anion (·O2–) is depicted in promoting the oxidation of lipids and related effects on adhesion, migration, and signaling (see text for details). AngII-mediated effects, including upregulation of NADPH oxidase (NOX) and LOX-1, are also indicated.
