REELIN and Schizophrenia:

Table 3.

Comparisons Between RELN-and DNMT1-Positive Neuronal Counts in Prefrontal Cortex (Brodmann area 10)

Layer mRNA Mean
NPS SP ANOVA
Data show the mean numbers of RELN or DNMT positive neurons in non-psychiatric subjects (NPS) and schizophrenia patients (SP). The in situ hybridization was performed on tissue that had a post-mortem interval (PMI) of between 5 and 7 hr. ANOVA=NPS vs SP: Cell number = #/mm2 x 10−3; NS = there is no statistically significant difference between groups: groups include 3 NPS and 7 SP.
For details of in situ hybridization histochemical methods, see (46).
I Reelin 1.87 0.72 <.001
Dnmt 1 1.13 1.74 <.001
II Reelin 2.63 1.17 <.001
Dnmt 1 2.23 3.37 <.002
III Reelin 1.63 0.79 <.001
Dnmt 1 2.03 2.94 NS
IV Reelin 1.57 1.10 <.028
Dnmt 1 2.23 3.60 <.018
V Reelin 1.53 1.03 <.001
Dnmt 1 1.77 2.84 <.040
VI Reelin 1.37 1.07 <.010
Dnmt 1 2.30 3.23 NS
PMI (hr) 6.6 6.14 NS

This Article

  1. MI February 2002 vol. 2 no. 1 47-57