REELIN and Schizophrenia:

Table 4.

Protracted Treatment with Methionine (1g/kg twice daily for 15 Days) Decreases Reelin Protein and mRNA Expression in Frontal Cortex of Wild-Type Mice (wtm) And Heterozygousreeler Mice (hrm).

Reelin 400 kDa protein Reelin mRNA
Mice Vehicle Methionine Vehicle Methionine
Reelin mRNA (attomol/μg RNA) was quantified using competitive RT-PCR (4); Reelin 400 k-Da protein (attomol/g of tissue) was quantified by western blot with recombinant reelin as an external standard (53); differences in tissue weigh are corrected for β-actin content. Each value is the mean ± SEM of 5 mice; *p<0.05 Student's t-test.
WTM 720 ± 120 400 ± 82* 175 ± 45 80 ± 1.5*
HRM 470 ± 40 285 ± 60* 90 ± 20 50 ± 10*

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  1. MI February 2002 vol. 2 no. 1 47-57
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