The GoLoco Motif: Heralding a New Tango Between G Protein Signaling and Cell Division

The arginine finger as a recurrent theme in G protein modulation. A. Arginine residues from both Gα_i1 (green) and the RGS14-GoLoco peptide (“R14GL”; red) contact GDP in the crystal structure. B. The use of an arginine finger has also been observed in the crystal structures of RhoGAP and RasGAP with their respective GTPases. Atomic coordinates taken from GoLoco‴Gα_i1 (1KJY), RhoGAP‴Rho (1TX4), and RasGAP‴Ras (1WQ1) were rendered using Molscript (49) and Raster3D (50).