Non-nuclear Actions of Estrogen: New Targets for Prevention and Treatment of Cardiovascular Disease

Table 1.

Tissue-Specific Effects of Selected SERMs

Breast Uterus Vasculature
Indirect effect Direct effect
Tamoxifen - + Lowers total cholesterol, ?
no effect on HDL ?
GW5638 - - Lowers total cholesterol ?
EM-800 - - Lowers total cholesterol NO-mediated vasodilation
and triglycerides
Raloxifene - - Lowers total cholesterol NO-mediated vasodilation
and triglycerides, ROS reduction
no effect on HDL
LY117018 ? - Lowers total cholesterol NO-mediated vasodilation

This Article

  1. MI July 2002 vol. 2 no. 4 219-228