Aurora-A Overexpression Leads to Override of the Microtubule-Kinetochore Attachment Checkpoint

Effect of overexpression of various forms of aurora-A in different cell lines. A. Overexpression of active aurora-A in immortalized or primary cells leads to polyploidy and centrosome amplification. B. Overexpression of inactive aurora-A in primary cells does not lead to polyploidy and centrosome amplification. C. Overexpression of active, hyperactive, or nondegradable aurora-A transforms immortalized cells but not primary cells. Associated references in parentheses.