- Institution: Stanford Univ Med Ctr Lane Med Lib/Periodical Dept/Rm L109
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LQT4 Gene: The “Missing” Ankyrin
Figure 2.
Cardiac ion channel subunits involved in LQTS. Topological maps of the voltage-gated α-subunit for INa (SCN5A) and α/β-subunits that make up IKr (HERG–KCNE2) and IKs (KCNQ1–KCNE1) are shown in relation to a typical ventricular action potential. Genetic mutations in these subunits are responsible for types 1, 2, 3, 5, and 6 of LQTS.
