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Galanin in Alzheimer Disease
Table 1.
GALR mRNA Expression in Brain Regions Associated with Cognition
| GALR subtype | Species GALR | Brain region | Detection assaya |
|---|---|---|---|
| aReferences in parentheses. RT-PCR, reverse-transcription polymerase chain reaction; RPA, ribonuclease protection assay; ISH, in situ hybridization. | |||
| GALR1 | Human | Cortex, hippocampus, amygdala | RT-PCR (86) |
| Rat | Cortex, hippocampus, amygdala | RPA (156) | |
| LS/HDB; entorhinal, insular, and piriform cortices; ventral CA1; amygdala | ISH (138) | ||
| LS/HDB, VDB, and nucleus basalis; entorhinal cortex; ventral dentate gyrus; central, medial, basomedial amygdaloid nuclei; amygdalohippocampal area | ISH (140) | ||
| GALR2 | Human | Hippocampus | RT-PCR (157) |
| Cortex, hippocampus, amygdala | RT-PCR (86) | ||
| Rat | Cortex, hippocampus, amygdala | RPA (156) | |
| Entorhinal/piriform cortices, hippocampus, amygdala | ISH (158) | ||
| Dentate gyrus granule layer | ISH (113) | ||
| MS/VDB; neo, piriform, and retrosplenial cortex; dentate gyrus; amygdala | ISH (138) | ||
| GALR3 | Rat | Cortex, hippocampus, amygdala | RPA (156) |
| MS/VDB, medial amygdaloid nucleus | ISH (139) | ||
