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Galanin in Alzheimer Disease
Table 4.
Ki of Nonspecific GALR Ligands at Cloned Rat GALRsa and Antagonist Actions of Chimeric GAL Peptides on Rat Behavioral Assaysb
| GAL ligand | GALR1 | GALR2 (nM range) | GALR3 | Antagonist actions in vivo |
|---|---|---|---|---|
| a Adapted from (80 , 83) ; b References in parentheses | ||||
| GAL (1–29) | 1 | 1 | 1 | |
| GAL (1–16) | 5 | 5 | 50 | |
| GAL (2–29) | 100 | 1 | 10 | |
| GAL (3–29) | 1000 | 1000 | 1000 | |
| C7 | ||||
| [GAL(1–13)-spantide-amide] | 20 | 20 | 1 | Inhibits nociceptive flexor reflex and blocks feeding (149 , 159) |
| M15 | ||||
| [GAL(1–13)-substance | 10 | 1 | 100 | Improves social recognition social memory task (160) |
| P(5–11)amide] Galantide | ||||
| M35 | ||||
| [GAL(1–13)-bradykinin(2–9)amide] | 1 | 1 | 10 | Facilitates acquisition of Morris spatial memory task (21) |
| M40 | ||||
| [GAL(1–13)-PPALALA-amide] | 5 | 1 | 50 | Facilitates delayed nonmatching to position working memory task (19) |
