S-Nitrosylation Signaling in Cell Biology

Table 1.

S-nitrosylation of Transription Factors

Transcription Factor	Cell Type	Site	Effect	Concentration of NO donor	References
NF-κB	A549	Cys⁶² on p50	Alters p50–p65 dimer formation	0.5–1 mM CSNO + TNFα	Marshall and Stamler (50)
	Jurkat		Inhibit IκBα formation	0.5 mM CSNO 0.5 mM DETA-NONOate + TNF	Marshall and Stamler (73)
	HSC-1 HeLa	(1) Blocks degradation of IB (2) Increases DNA binding activity	Thioredoxin		Hirota et al. (74)
	Human saphenous vein endothelial cells	Induction and stabilization of IκBα		0.2-0.5 mM GSNO or 0.5 mM SNP + TNF	Peng et al. (75)
OxyR	E. coli	Cys¹⁹⁹	Response to nitrosative stress	0.2 mM SNO-Cys	Kim et al. (52)
HIF-1α	BPAEC		Stabilization of α subunit	0.1 mM GSNO, 0.5 mM NOC-18	Palmer et al. (42)
Sp1–Sp3	A549		Switch in DNA Binding Activity from Sp1 (high conc.) to Sp3 (low conc.)	0.01-0.5 mM GSNO	Zaman et al. (48)