CaMKII, an Enzyme on the Move: Regulation of Temporospatial Localization

Table 1.

Proteins that Interact with CaMKII

Interacting protein Interaction domain of CaMKII Interaction domain of partner Interaction inhibitor(s) Interaction protein enhancer(s) Function hypothesized by authors References
CaMKII Association domain Association domain Form CaMKII holoenzyme (93, 94)
Catalytic domain Regulatory domain CaMKII autoregulatory domain inhibitor peptides: AC-2, AIP Low pH, ATP, Ca2+-CaM Sequester and inactivate α CaMKII in ischemia (95, 96)
α-actinin 1 Catalytic and regulatory domains EF hand-containing C-terminus EDTA Ca2+ Modulate the association of α CaMKII with actin cytoskeleton and access to putative PSD substrates (GluR1, NR2A, NR2B) (97)
α-actinin 4 Kinase domain EF hand-containing C-terminus Tether α CaMKII to NMDA receptor complex at PSD (65)
F-actin Variable region of β CaMKII CaM Localize α CaMKII to dendritic spines via β CaMKII (19)
Myosin-V aa 760–1436 Deliver myosin-bound CaM to activate CaMKII; Regulate organelle transport in mitosis (42)
Synapsin I Regulatory domain C-terminus Regulation of synaptic vesicle pools (98)
Syntaxin 1A Linker EGTA PP1 activity Munc18 CaMKII oligomerization and autophosphorylation (required) Recruit SNAP-25 and Synaptotagmin for exocytosis in presynaptic terminals (99)
Synaptotagmin EGTA Phosphatase activity Ca2+ Regulate SNARE complex/exocytosis in presynaptic terminals (100)
Camguk Regulatory domain pT305 pT306 Ca2+ AMP-PNP Localize CaMKII and regulate its activity at in press synapses depending on local Ca2+ levels Lu et al.,
PP2A δB CaMKII Catalytic subunit Ca2+-induced cardiac hypertrophic response (91)
NR1 C-terminus α-actinin 2 pT286 Recruit CaMKII to PSD (84)
NR2A C-terminus, aa 1389–1464 PSD-95 pT286 Recruit CaMKII to PSD and modulate channel activity for regulation of LTP and LTD of synaptic strength (80, 101)
NR2B C-terminus, aa 839–1120 pT286 Recruit CaMKII to PSD and modulate channel activity for regulation of LTP and LTD of synaptic strength (80, 81, 88)
C-terminus, aa 1259–1310 Ca2+-CaM
Eag K+ channel Catalytic domain C-terminus, aa 773–794 Ca2+-CaM, pT286 Scaffold and activate CaMKII Sun et al. submitted
L- type Ca2+ channel α1c C-terminus pT286 and/or Ca2+-CaM Ca2+-dependent facilitation (90)
Cdk5 activators p35, p39 Catalytic and regulatory domains C-terminal Cdk5 binding region EDTA, EGTA, KN62, KN93, MK801(major) CNQX (minor) Ca2+ Glu–Gly Enhance Cdk5 localization to putative PSD substrates (97)
SynGAP-β C-terminus pT286 Recruit and anchor nonphosphorylated CaMKII to PSD (102)
Densin-180 Association domain C-terminus pT286 Recruit and anchor CaMKII to PSD (38, 65)
α KAP Association domain Direct CaMKII to the sarcoplasmic reticulum in skeletal muscle (47, 48)
Karyopherin/Importin NLS in variable region of αB and δB CaMKII Phosphorylation by CaMKIV and CaMKI Target CaMKII to nucleus for regulation of gene expression (23)
Tubulin Bind CaMKII to the cytoskeleton (103)
β 1 Integrin Modulation of β 1 integrin association with the actin cytoskeleton (104)
Rad GTPase Modulation of rad function (105)
Projectin pT286 Activate CaMKII activity w/o CaM in muscle (106)
CaM-KIIN Catalytic domain C-terminus, aa 43–69 CaMKII inhibitor (107)
Raf-1 KN93 Integrin activation Regulation of ERK signaling (108)

This Article

  1. MI October 2003 vol. 3 no. 7 386-403