A Neurogenic Theory of Depression Gains Momentum

Table 1.

Response of Neurogenesis to Administration of Neuroleptic Drugs1

Medication Mechanism Effect on Neurogenesis Reference
1 For detailed reviews see (1) and (19).
2 SNRI, selective norepinephrine reuptake inhibitor; SSRE, selective serotonin reuptake enhancer; SSRI, selective serotonin reuptake inhibitor; MAOI, monoamine oxidase inhibitor; TCA, tricyclic antidepressant.
Desipramine SNRI2 + 7
Tianeptine SSRE + 26
Fluoxetine SSRI + 7, 9, 18, 27
Reboxetine SNRI + 18
Tranylcypromine MAOI + 18
Imipramine TCA + 7
Haloperidol Antipsychotic No effect 9
+ 28
Lithium Mood stabilizer No effect 29
+ 30

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  1. MI December 2003 vol. 3 no. 8 441-444
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