Biochemical Mechanisms of Cyclosporine Neurotoxicity

Table 2.

Comparing Symptoms of Cyclosporine-Induced Neurotoxicity and Mitochondrial Encephalomyopathies

	MEALS	MERRF	Cyclosporine
MELAS, mitochondrial encephalopathy with lactic acidosis and stroke-like episodes; MERRF, myoclonus epilepsy with ragged red fibers. +, indicates symptom is present; O, indicates symptom not reported. Data collected from (7–9, 75, 76).
Tremor	+	+	+
Weakness	+	+	+
Seizures	+	+	+
Headache	+	+	+
Dementia	+	+	+
Cerebral Blindness	+	O	+
Stroke-Like Episodes	+	+	+
Paresthesia	O	O	+
Lactic Acidosis	+	+	+