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The NAADP Receptor: New Receptors or New Regulation?
Table 1.
Pharmacology of the Inhibition of NAADP-Induced Ca2+ Release
| Cell/Preparation | NAADP inactivation | Ryanodine/ Ruthenium Red | 8-sub-cADPR | Heparin | Thapsigargin | Bafilomycin | DHP | References |
|---|---|---|---|---|---|---|---|---|
| RED, reduced; ND, not determined; 8-sub-cADPR, 8-substituted inhibitor analogs of cADPR; DHP, dihydropyridine; YES, inhibition; NO, no inhibition. | ||||||||
| Sea urchin egg (homogenate) | YES | NO | NO | NO | NO | YES | YES | (3, 11) |
| Sea urchin egg (intact) | YES | NO | NO | YES | NO | YES | YES | (11) |
| Brain microsomes | ND | NO | NO | NO | ND | ND | YES | (40) |
| Aplysia neuron | ND | NO | NO | NO | ND | ND | ND | (41) |
| Frog NMJ | ND | NO | ND | NO | NO | ND | ND | (42, 43) |
| Rat cortical neuron | ND | NO | ND | NO | NO | YES | ND | (44) |
| Heart microsomes | ND | NO | NO | NO | ND | ND | YES | (52) |
| Mesangial cells | ND | NO | NO | NO | ND | ND | YES | (60) |
| Starfish oocyte | YES | NO | NO | NO | YES | ND | YES | (61) |
| Ascidian oocyte | YES | NO | ND | NO | ND | ND | ND | (62) |
| Rat aortic myocytes | ND | NO | NO | NO | ND | ND | YES | (51) |
| Rat pulmonary arterial myocyte | ND | RED | RED? | NO | NO | YES | ND | (49, 50) |
| Jurkat T cell | YES | RED | RED? | NO | ND | ND | YES | (16, 56) |
| Pancreatic acinar cells | YES | YES | YES | YES | YES/RED | YES/RED | ND | (20, 28, 36) |
| Pancreatic acinar cell nuclear envelope | YES | YES | ND | NO | YES | NO | ND | (35) |
| Pancreatic beta cell | YES | NO | NO | NO | NO | ND | ND | (36) |
| MIN6 SGs | ND | NO | NO | NO | NO | YES | YES | (48) |
| MIN6 cell | YES | NO | NO | NO | NO | YES | ND | (36, 46) |
| RYR1 (bilayer) | ND | YES | ND | ND | ND | ND | ND | (53) |
| RYR2 (bilayer) | ND | YES | ND | ND | ND | ND | ND | (54) |
| Plant microsomes | YES | YES | NO | NO | ND | ND | NO | (57) |
