NEUROGENIC INFLAMMATION AND MIGRAINE: IMPLICATIONS FOR THE THERAPEUTICS

Table 1.

Three Mechanisms for the Selective Inhibition of Dural PPE

Agent Mechanism
a Tachykinin receptor 1.
b Endothelin receptor type B.
c Functional designation only; these agents prevent NI-inducing neuropeptide “extravasation” in tregeminal terminals.
Lanepitant (i.e., LY-303870)
GR205171
L-758298
FK 888 TACR1a antagonists
Dapitant (i.e., RPR-100893)
Bosentan EDNRBb antagonist
CP-122,288
4991W93 “Extravasation receptor” antagonistsc

This Article

  1. MI October 2005 vol. 5 no. 5 304-311