Loss of Caspase-8 in Tumor Cells: Mechanism to Overcome Integrin-Mediated Death?

The integrin receptors and their major ECM ligands. Each heterodimeric transmembrane integrin receptor consists of one α and one β subunit. α subunits: α₁, α₂, α₃, α₄, α₅, α₆, α₇, α₈, α₉, α₁₀, α₁₁, α_v; β subunits: β₁, β₃, β₄, β₅, •β₆, β₇, β₈. Composition of each subunit determines ligand specificity. Figure depicts seventeen distinct integrins and their binding preferences for collagen, laminin, tenascin, fibronectin, and vitronectin.