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Roadmap or Roadkill: A Pharmacologist’s Analysis of the NIH Molecular Libraries Initiative
Table 2.
Roadmap Research: Grants in Neurobiology
| Grant Title | Grant Type | Principal Investigator |
|---|---|---|
| Development of a high throughput screening Galanin 3 receptor assay | R21 | Steven J. Brown, Scripps |
| A cell-based screen for inhibitors of intracellular Abeta aggregation | R21 | Matthew P. Delisa, Cornell |
| Chemical probes for uncovering differential regulators of apoptosis in cells | R03 | Monanish Deshmukh, UNC |
| HTS technology for discovery of drugs targeting GPCR oligomers | R21 | Pyare L. Khanna, DiscoveRx Corporation |
| A cell-based screen for small molecule binders of mutant huntingtin messenger RNA | R21 | Robert E. Hughes, Buck Institute for Age Research |
| Inhibitor screens for five MAPK kinase kinases important in human disease | R21 | Gary L. Johnson, UNC |
| Assay development to identifiy palmitoylation inhibitors of neuronal proteins | R21 | Maurine E. Linder, Washington U |
| Multiplexed flow cytometry screens for RGS inhibitors | R21 | Richard R. Neubig, University of Michigan |
| High-throughput screening assay development for axonopathic neurodegeration | R21 | Norbert Perrimon, Harvard |
| Assay development relating to the HTS of the neuropeptide Y-Y2 receptor | R21 | Claes Wahlestedt, Scripps |
| Discovery of novel allosteric modulators of the M1 muscarinic receptor | XO1 | P. Jeffrey Conn, Vanderbilt |
| Ligands for premortem diagnosis and treatment of Alzheimer’s disease | XO1 | Jeff A. Kuret, Ohio State |
| Discovery of novel allosteric agonist of the M4 muscarinic receptor | XO1 | Colleen M. Niswender, Vanderbilt |
| EphA4 receptor antagonists for nervous system repair | XO1 | Elena B. Pasquale, Burnham Institute |
| Allosteric modulators of D1 receptors | XO1 | Val J. Watts, Purdue |
