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Unraveling the Structure of the Variola Topoisomerase IB-DNA Complex: A Possible New Twist on Smallpox Therapy
Figure 1.
Crystal structures of the variola and human topoisomerase IB-DNA cleavage complexes. A. The variola topoisomerase IB–DNA cleavage complex. The anticancer drug camptothecin has been modeled into the complex. B. The human topoisomerase IB–DNA cleavage complex crystallized in the presence of camptothecin. Adapted from Perry et al. (4) Reprinted from
Mol. Cell, vol 23, 351© 2006, with permission from Elsevier.
