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REGULATION OF DRUG TRANSPORTERS: DURING INFECTION AND INFLAMMATION
Figure 2.
Hepatic drug transporters whose expression is influenced by inflammation. P-glycoprotein (ABCB1), MDR2 (ABCB4), BSEP (ABCB11), MRP2 (ABCC2) and BCRP (ABCG2) are involved in the efflux of substrates into bile, whereas MRP3 (ABCC3) mediates basolateral efflux into plasma. Sinusoidal uptake transporters include NTCP (Slc10a1), OATP1 (Slc21a1) and OATP2 (Slc21a5), although OATP1 and OATP2 are also involved in substrate efflux.
