Diversity of the Neurotoxic Conus Peptides

Table 1.

Examples of Gene Superfamilies

Gene superfamily (Major framework) Conotoxin families Target family (mechanism)
A (CC-C-C) α Nicotinic receptors (competitive antagonist)
M (CC-C-C-CC) μ Na+ channels (channel blocker)
κM K+ channels (channel blocker)
O (C-C-CC-C-C) ω Ca2+ channels (channel blocker)
δ Na+ channels (inhibitor of inactivation)
I (C-C-CC-CC-C-C) ι Na+ channels (activation enhancers)

This Article

  1. MI October 2007 vol. 7 no. 5 251-260