Diversity of the Neurotoxic Conus Peptides

Table 2.

Concerted Evolution: Families of Conopeptides and Families of Targets

Conus species	Ligand family: Specific peptide	Target family: Subtype targeted
	α-conotoxins	Nicotinic receptors
C. magus	α-MI	α1δ-containing
C. aulicus	α-AuIB	α3β4
C. regius	α-RgIA	α9α10
C. purpurascens	α-PIA	α6β3β2
C. imperialis	α-ImI	α7
	ω-conotoxins	Voltage-gated Ca²⁺ channels
C. magus	ω-MVIIA	Ca_v 2.2
C. magus	ω-MVIIC	Ca_v 2.1