Targeting Cancer Stem Cells with Phytochemicals

Table 1.

Targeting Cancer Stem Cell Properties

Targeted process Specific Target(s) Phytochemical(s) [origin]
P-gp, P-glycoprotein; MRP, multidrug resistance-related protein;ABCG2, ATP-binding cassette transporter G2; MXR, mitoxantrone resistance protein; NF-κB, Nuclear factor-kappaB; RAR, Retinoic Acid Receptor.
P-gp Epigallocatechin gallate (EGCG) [green tea]
Drug efflux MRP1, 4, and 5 Quercitin [capers, apples, berries]
 Silymarin [blessed milk thistle]
ABCG2 Curcumin [tumeric]
P-gp, ABCG2 (MXR), and MRP1 Tetrahydrocurcumin [tumeric]
Apoptosis NF-κB Parthenolide [feverfew]
Differentiation RAR Retinoic acid [carrots, spinach, eggs]

This Article

  1. MI August 2008 vol. 8 no. 4 174-184