A Review of Antioxidants and Alzheimer’s Disease
Bradford Frank M.D., MPH, MBA.Sanjay Gupta M.D.
pages: 269 - 286
- DOI: 10.1080/10401230500296428
- Version of record first published: 01Oct2005
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Abstract:
Background . In this article, we review a diverse body of research and draw conclusions about the usefulness, or lack there-of, of specific antioxidants in the prevention of Alzheimer’s disease (AD).
Methods . The National Library of Medicine's database was searched for the years 1996–2004 using the search terms “Alzheimer's, anti-oxidants, antioxidants.”
Results . Over 300 articles were identified and 187 articles were selected for inclusion based on relevance to the topic. Agents that show promise in helping prevent AD include: 1) aged garlic extract, 2) curcumin, 3) melatonin, 4) resveratrol, 5) Ginkgo biloba extract, 6) green tea, 7) vitamin C and 8) vitamin E.
Conclusions . While the clinical value of antioxidants for the prevention of AD is often ambiguous, some can be recommended based upon: 1) epidemiological evidence, 2) known benefits for prevention of other maladies, and 3) benign nature of the substance. Long-term, prospective studies are recommended.