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Figure 3: Qa-1-CD94/NKG2A dependent suppression of delayed type hypersensitivity (DTH) response in anterior chamber associated immune deviation (ACAID) model in mice. ACAID associated suppression of antigen specific DTH is observed in CD94/NKG2A expressing mouse strain, but not in CD94/NKG2A deficient DBA/2J mice. [79] (a) Schematic representation of ACAID model, which illustrate ACAID mediated suppression of antigen mediated DTH in mice. (b) Suggested role of CD94/NKG2A-Qa-1 system for CD8 + immunosuppressive Tregs in ACAID [79] , where transforming growth factor beta may influence the generation of CD8 + Tregs [104],[105],[106],[107]

Figure 3: Qa-1-CD94/NKG2A dependent suppression of delayed type hypersensitivity (DTH) response in anterior chamber associated immune deviation (ACAID) model in mice. ACAID associated suppression of antigen specific DTH is observed in CD94/NKG2A expressing mouse strain, but not in CD94/NKG2A deficient DBA/2J mice. <sup>[79]</sup> (a) Schematic representation of ACAID model, which illustrate ACAID mediated suppression of antigen mediated DTH in mice. (b) Suggested role of CD94/NKG2A-Qa-1 system for CD8 <sup>+</sup> immunosuppressive Tregs in ACAID <sup>[79]</sup> , where transforming growth factor beta may influence the generation of CD8 <sup>+</sup> Tregs <sup>[104],[105],[106],[107]</sup>