Journal Facts

Journal
BoneKEy Reports
ISSN
2047-6396
Volume
1
Year
2012

Article Facts

Title
Mechanisms of multiple myeloma bone disease
DOI
10.1038/bonekey.2012.135
Authors

Deborah L Galson
Rebecca Silbermann
G David Roodman

Online Date
08/01/2012

Article Links

BoneKEy Reports | Reviews

Mechanisms of multiple myeloma bone disease

Deborah L Galson
Rebecca Silbermann
G David Roodman


DOI:10.1038/bonekey.2012.135

Abstract

Multiple myeloma is the second most common hematological malignancy and the most frequent cancer to involve the skeleton. Multiple myeloma bone disease (MMBD) is characterized by abnormal bone remodeling with dysfunction of both bone resorption and bone formation, and thus can be used as a paradigm for other inflammatory bone diseases, and the regulation of osteoclasts and osteoblasts in malignancy. Studies of MMBD have identified novel regulators that increase osteoclastogenesis and osteoclast function, repress osteoblast differentiation, increase angiogenesis, or permanently alter stromal cells. This review will discuss the current understanding of mechanisms of osteoclast and osteoblast regulation in MMBD, and therapeutic approaches currently in use and under development that target mediators of bone destruction and blockade of bone formation for myeloma patients, including new anabolic therapies.

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