Journal Facts

Journal
BoneKEy Reports
ISSN
2047-6396
Volume
1
Year
2012

Article Facts

Title
Histomorphometric interpretation of bone biopsies for the evaluation of osteoporosis treatment
DOI
10.1038/bonekey.2012.47
Authors

Juliet E Compston

Online Date
04/04/2012

Article Links

BoneKEy Reports | Reviews

Histomorphometric interpretation of bone biopsies for the evaluation of osteoporosis treatment

Juliet E Compston


DOI:10.1038/bonekey.2012.47

Abstract

Bone histomorphometry is a valuable tool in the evaluation of bone safety and the mechanism of action of drugs used in the treatment of osteoporosis. Recent studies in patients treated with anti-resorptive agents have highlighted technical issues, in particular, related to the calculation of dynamic indices of bone turnover using fluorochrome labelling. This review addresses the need for standardised approaches for overcoming these problems in order to enable valid comparison of the effects of different interventions on bone remodelling.

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