Journal Facts

Journal
BoneKEy Reports
ISSN
2047-6396
Volume
5
Year
2016

Article Facts

Title
Preclinical animal models of multiple myeloma
DOI
10.1038/bonekey.2015.142
Authors

Seint T Lwin
Claire M Edwards
Rebecca Silbermann

Online Date
02/03/2016

Article Links

BoneKEy Reports | Laboratory Methods

Preclinical animal models of multiple myeloma

Seint T Lwin
Claire M Edwards
Rebecca Silbermann


DOI:10.1038/bonekey.2015.142

Abstract

Multiple myeloma is an incurable plasma-cell malignancy characterized by osteolytic bone disease and immunosuppression. Murine models of multiple myeloma and myeloma bone disease are critical tools for an improved understanding of the pathogenesis of the disease and the development of novel therapeutic strategies. This review will cover commonly used immunocompetent and xenograft models of myeloma, describing the advantages and disadvantages of each model system. In addition, this review provides detailed protocols for establishing systemic and local models of myeloma using both murine and human myeloma cell lines.

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