BoneKEy Reports | Laboratory Methods

Mouse models for studying prostate cancer bone metastasis

Jinlu Dai
Janine Hensel
Ning Wang
Marianna Kruithof-de Julio
Yusuke Shiozawa

---

DOI:10.1038/bonekey.2016.4

Abstract

Once tumor cells metastasize to the bone, the prognosis for prostate cancer patients is generally very poor. The mechanisms involved in bone metastasis, however, remain elusive, because of lack of relevant animal models. In this manuscript, we describe step-by-step protocols for the xenograft mouse models that are currently used for studying prostate cancer bone metastasis. The different routes of tumor inoculation (intraosseous, intracardiac, intravenous and orthotopic) presented are useful for exploring the biology of bone metastasis.

---

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.