IBMS BoneKEy | Perspective
Bone cells, osteoprogenitors, and hematopoiesis
Paolo Bianco
DOI:10.1138/20080328
Abstract
The role of bone cells in regulating hematopoiesis is increasingly being brought to general attention by recent studies. Data from murine models with mutations targeted to, or affecting the osteoblastic lineage have revealed a potential role of osteoblastic cells in regulating the hematopoietic stem cell niche. In addition, studies using transplantation systems in which the hematopoietic microenvironment can be transferred to heterotopic sites are revealing the specific role of individual subsets of osteogenic cells, defined by surface phenotype. In particular, the possibility is emerging that skeletal stem cells and hematopoietic stem cells may share a microanatomic location in the bone marrow, and interact with each other. While highlighting a somewhat neglected, and yet physiologically major, function of osteogenic cells, these data promise to reveal mechanisms underlying the “seed and soil” interaction between bone- and blood-borne hematopoietic progenitors, and also cancer cells.
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