IBMS BoneKEy | Perspective

CT-based visualization and quantification of bone microstructure in vivo

G Harry van Lenthe
Ralph Müller

---

DOI:10.1138/20080348

Abstract

It is well-accepted that in addition to bone volume, trabecular bone microstructure is an important factor influencing bone strength, which in turn is the most important bone parameter indicating bone fracture risk. The objective of this article is to describe some of the computed tomography (CT)-based techniques used to measure the microarchitectural aspects of bone quality, how these can be quantified and how these quantitative endpoints can be used in the assessment of bone competence. Microarchitectural bone imaging is a nondestructive, noninvasive, and precise procedure with which both the apparent density and trabecular microstructure of intact bones and bone samples can be assessed in a single measurement. Recently introduced high-resolution in vivo CT imaging systems now allow repetitive measurements of bone microarchitecture so that small local trabecular changes can be monitored over time. The procedure can help improve predictions of fracture risk, clarify the pathophysiology of skeletal diseases, and define the response to therapy and interventions. Hopefully, this improved understanding will lead to more successful approaches in the prevention and treatment of age- and disease-related fractures.

---

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.