IBMS BoneKEy | Perspective

Nitrogen-containing bisphosphonates and human γδ T cells

Ismahène Benzaid
Philippe Clézardin

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DOI:10.1138/20100450

Abstract

Bisphosphonates, especially nitrogen-containing bisphosphonates (N-BPs), are widely used to block bone destruction associated with bone metastasis because they are effective inhibitors of osteoclast-mediated bone resorption. In addition to their antiresorptive activity, growing preclinical evidence shows that N-BPs have direct and indirect anti-tumor activities. Some of the anti-tumor activities of N-BPs are associated with human γδ T cells that are key players in the interface between innate and adaptive immunity. This review examines the molecular and cellular mechanisms through which N-BPs stimulate the expansion and anti-tumor activity of human γδ T cells, suggesting a new role for N-BPs in cancer immunotherapy.

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