IBMS BoneKEy | Perspective

Osteonecrosis of the jaw: Recent clinical and preclinical advances

Matthew R Allen
Salvatore L Ruggiero

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DOI:10.1138/20110500

Abstract

Although first described nearly seven years ago and despite receiving a significant amount of attention in the scientific and lay community, it has only been in the past few years that significant progress toward understanding osteonecrosis of the jaw (ONJ) has occurred. The purpose of this Perspective is to update recent clinical aspects related to defining and treating ONJ and also significant preclinical advances in animal model development. Although we still have much to learn about this condition, progress over the past few years is encouraging and certainly headed in the right direction.

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