IBMS BoneKEy | Perspective

Anti-TNFα therapy and prevention of bone loss in rheumatoid arthritis

Christian Roux

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DOI:10.1138/20110501

Abstract

Systemic osteoporosis is a well-known complication of rheumatoid arthritis (RA). The bone loss is related to the characteristics of the patient (typically a postmenopausal woman), corticosteroid therapy, and the underlying disease. The increase in bone resorption related to chronic inflammation is increasingly recognized. Anti-TNFα therapy is an effective therapy for RA, and could have a positive effect on bone loss through its potent anti-inflammatory effect. A tight control of inflammation is now the gold standard in RA, and is an effective way to prevent bone loss.

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