IBMS BoneKEy | Clinical Cases

A natural history of bisphosphonate use in Paget’s disease of bone

Margaret Seton
Thomas Raphael

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DOI:10.1038/bonekey.2016.3

Abstract

The discovery and development of bisphosphonates for the treatment of bone disorders depended on early-clinical trials involving patients with Paget’s disease of bone (PDB). The patients benefited from these with easing of pain and often a biochemical remission. In turn, the physician–scientists learned more about the mechanism of action of these drugs, translating this into greater potency and safer therapeutic margins in the new-generation bisphosphonates. Mr Raphael has PDB. He has charted his response to bisphosphonates over the past 30 years, his graphs depicting this remarkable history of the evolution of these drugs and their pattern of efficacy.

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