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Human Gene Therapy: A Role for the Primary Care Physician
Cynthia J. Schmeichel, PhD;
Jerod M. Loeb, PhD
Arch Fam Med. 1992;1(1):113-120.
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20. Lynch CM, Clowes MM, Osborne WRA, Clowes AW, Miller DA. Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: a model for gene therapy. Proc Natl Acad Sci USA. 1992;89:1138-1142.
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21. Rosenfeld MA, Siegried W, Yoshimura K, et al. Adenovirus-mediated transfer of a recombinant alpha1-anti-trypsin gene to the lung epithelium in vivo. Science. 1991;252:431-434.
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35. Golumbek PT, Lazenby AJ, Levitsky HI, et al. Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science. 1991;254:713-716.
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36. Moolten FL, Wells JM, Heyman RA, Evans RM. Lymphoma regression induced by gancyclovir in mice bearing a herpes thymidine kinase transgene. Hum Gene Ther. 1990;1:125-134.
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37. Mullen CA, Kilstrup M, Blaese RM. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc Natl Acad Sci USA. 1992;89:33-37.
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38. Bernstein K. Gene therapy trials for HIV patients. BioWorld Today. 1992;3(32):1.
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39. Nabel EG, Plautz G, Nabel GJ. Site-specific gene expression in vivo by direct gene transfer into the arterial wall. Science. 1990;249:1285-1288.
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40. Kolberg R. Animal models point the way to human clinical trials. Science. 1992;256:772-773.
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