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Multicenter Comparison of Clarithromycin and Amoxicillin-Reply
Karen H. Calhoun, MD
University of Texas Medical Branch Galveston
Arch Fam Med. 1994;3(7):575.
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In reply
The aim of this study1 was to compare clarithromycin with another commonly used antibiotic in the treatment of acute maxillary sinusitis. Amoxicillin was chosen because amoxicillin (and ampicillin) are frequently used first-line antibiotics for the treatment of sinusitis. Gwaltney2 recommends several drugs, including ampicillin or amoxicillin, for initial treatment of uncomplicated communityacquired sinusitis. These drugs are not effective against β-lactamase^producting strains of bacteria, and other drugs are better choices in geographic areas where Haemophilus or Moraxella isolates are often β-lactam positive.
The sample size estimates were based on the 142 recruited patients. After the elimination of nonevaluable patients, 116 remained. It is true that with an infinite sample size, we could detect very small differences between groups; we were, however, limited to reporting on the data we obtained.
We have reanalyzed the numbers and the 2x2 table. A  2 analysis gave a 2 of 3.27, which
. . . [Full Text PDF of this Article]
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